Drug eruption
☆ Liphethong tsa 2022 Stiftung Warentest tse tsoang Jeremane, khotsofalo ea bareki ka ModelDerm e ne e le tlase hanyane ho feta lipuisano tse lefelloang tsa telemedicine.
Drug eruption e tšoauoa ka ho ama 'mele oohle.
References
Karabelo ea letlalo e bakoang ke meriana, e tsejoang e le ho phatloha ha lithethefatsi, ka linako tse ling e ka ba mpe haholo. Maikutlo ana a matla, a bitsoang severe cutaneous adverse drug reactions (SCARs) , a nkoa e le a behang bophelo kotsing. Li kenyelletsa maemo a kang Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Le hoja SCARs e sa tloaeleha, hoo e ka bang 2% ea bakuli ba sepetlele baa li utloa.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Mosali ea lilemo li 31 o ile a etela lefapha la dermatology ka lesela le khubelu le se nang bohloko karolong e ka holimo ea leoto la hae le letona. O ile a noa tekanyo e le 'ngoe ea doxycycline (100 mg) letsatsi pele ho moo, ho latela kalafo ea laser ea picosecond bakeng sa maqeba a makhopho. Selemong se fetileng, o ile a ba le bothata bo tšoanang sebakeng se le seng ka mor'a ho nka tekanyo e tšoanang ea phekolo ea post-laser ea doxycycline. Ha a na nalane ea bohlokoa ea bongaka ebile ha a na matšoao a mang, joalo ka feberu, sebakeng sa hae kapa 'meleng oa hae kaofela.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) le toxic epidermal necrolysis (TEN) ke mefuta e 'meli ea karabelo e matla ea letlalo, e fapaneng le maemo a mang a letlalo joalo ka erythema multiforme major le staphylococcal scalded skin syndrome, hammoho le karabelo ea lithethefatsi. SJS/TEN ke karabelo e sa tloaelehang le e matla e bakang tšenyo e atileng ea letlalo le lera la mucous, hangata ka matšoao a tsamaiso. Ho feta 80% ea linyeoe, meriana ke eona sesosa.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Ho phatloha ha lithethefatsi ho fumanoa haholo-holo ho tloha historing ea bongaka le tlhahlobo ea bongaka. Tlhahlobo ea letlalo, liteko tsa mali kapa liteko tsa immunology le tsona li ka ba molemo.
Mehlala ea lithethefatsi tse tloaelehileng tse bakang ho phatloha ke lithibela-mafu le lithethefatsi tse ling tse thibelang likokoana-hloko, lithethefatsi tsa sulfa, li-nonsteroidal anti-inflammatory drugs (NSAID), li-chemotherapy bakeng sa malignancies, anticonvulsants le psychotropic drugs.
○ Tlhahlobo le Kalafo
Haeba u na le feberu (thecheso e eketsehileng ea 'mele), u lokela ho ea ngakeng kapele kamoo ho ka khonehang. Sethethefatsi se belaelloang se lokela ho emisoa (mohlala, lithibela-mafu, li-non-steroidal anti-inflammatory drugs). Pele u etela sepetlele, li-antihistamine tsa molomo tse kang cetirizine kapa loratadine li ka thusa bakeng sa ho hlohlona le lekhopho.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Teko ea mali (CBC, LFT, palo ea eosinophil)
Oral steroids le antihistamines ka lengolo la ngaka